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Recent progress and novel approaches to treating atypical teratoid rhabdoid tumor.
Alva, Elizabeth; Rubens, Jeffrey; Chi, Susan; Rosenberg, Tom; Reddy, Alyssa; Raabe, Eric H; Margol, Ashley.
Afiliación
  • Alva E; Division of Pediatric Hematology-Oncology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA.
  • Rubens J; Division of Pediatric Oncology, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Chi S; Dana-Farber Cancer Institute, Children's Hospital Boston, Boston, MA, USA.
  • Rosenberg T; Dana-Farber Cancer Institute, Children's Hospital Boston, Boston, MA, USA.
  • Reddy A; Departments of Neurology and Pediatrics, University of California San Francisco, San Francisco, CA, USA.
  • Raabe EH; Division of Pediatric Oncology, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: eraabe2@jhmi.edu.
  • Margol A; Children's Hospital Los Angeles, Los Angeles, CA, USA; Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. Electronic address: amargol@chla.usc.edu.
Neoplasia ; 37: 100880, 2023 03.
Article en En | MEDLINE | ID: mdl-36773516
ABSTRACT
Atypical teratoid rhabdoid tumors (AT/RT) are malignant central nervous system (CNS) tumors that occur mostly in young children and have historically carried a very poor prognosis. While recent clinical trial results show that this tumor is curable, outcomes are still poor compared to other central nervous system embryonal tumors. We here review prior AT/RT clinical trials and highlight promising pre-clinical results that may inform novel clinical approaches to this aggressive cancer.
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Texto completo: 1 Colección: 01-internacional Asunto principal: Teratoma / Neoplasias del Sistema Nervioso Central / Tumor Rabdoide Tipo de estudio: Prognostic_studies Límite: Child / Child, preschool / Humans / Infant Idioma: En Revista: Neoplasia Asunto de la revista: NEOPLASIAS Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
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Buscar en Google

Texto completo: 1 Colección: 01-internacional Asunto principal: Teratoma / Neoplasias del Sistema Nervioso Central / Tumor Rabdoide Tipo de estudio: Prognostic_studies Límite: Child / Child, preschool / Humans / Infant Idioma: En Revista: Neoplasia Asunto de la revista: NEOPLASIAS Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos