Inhibition effect of 1-acetoxy-6&#945;-(2-methylbutyryl)eriolanolide toward soluble epoxide hydrolase: Multispectral analysis, molecular dynamics simulation, biochemical, and in vitro cell-based studies.

Zhang, Juan; Yang, Fang-Yu; Zhu, Qi-Meng; Zhang, Wen-Hao; Zhang, Min; Yi, Jing; Wang, Yan; Zhang, Hou-Li; Liang, Guo-Biao; Yan, Jian-Kun; Sun, Cheng-Peng

Inhibition effect of 1-acetoxy-6α-(2-methylbutyryl)eriolanolide toward soluble epoxide hydrolase: Multispectral analysis, molecular dynamics simulation, biochemical, and in vitro cell-based studies.

Zhang, Juan; Yang, Fang-Yu; Zhu, Qi-Meng; Zhang, Wen-Hao; Zhang, Min; Yi, Jing; Wang, Yan; Zhang, Hou-Li; Liang, Guo-Biao; Yan, Jian-Kun; Sun, Cheng-Peng.

Afiliación

Zhang J; College of Pharmacy, Dalian Medical University, Dalian, China; School of Pharmaceutical Sciences, Health Science Center, Shenzhen University, Shenzhen, China.
Yang FY; Department of Neurosurgery, General Hospital of Northern Theater Command, Shenyang, China.
Zhu QM; College of Pharmacy, Dalian Medical University, Dalian, China.
Zhang WH; College of Pharmacy, Dalian Medical University, Dalian, China.
Zhang M; College of Pharmacy, Dalian Medical University, Dalian, China.
Yi J; College of Pharmacy, Dalian Medical University, Dalian, China.
Wang Y; College of Pharmacy, Dalian Medical University, Dalian, China.
Zhang HL; College of Pharmacy, Dalian Medical University, Dalian, China.
Liang GB; Department of Neurosurgery, General Hospital of Northern Theater Command, Shenyang, China. Electronic address: liangguobiao6708@vip.163.com.
Yan JK; School of Pharmacy, Hebei University of Chinese Medicine, Shijiazhuang, China. Electronic address: jkyan007@foxmail.com.
Sun CP; College of Pharmacy, Dalian Medical University, Dalian, China. Electronic address: suncp146@163.com.

Int J Biol Macromol ; 235: 123911, 2023 Apr 30.

Article en En | MEDLINE | ID: mdl-36878397

Asunto(s)

Epóxido Hidrolasas; Simulación de Dinámica Molecular; Epóxido Hidrolasas/química; Transducción de Señal; Regulación de la Expresión Génica; Factor de Necrosis Tumoral alfa/metabolismo

Palabras clave

Inflammation; Molecular dynamics simulation; Multispectral analysis; Sesquiterpenoids; Soluble epoxide hydrolase

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Texto completo: 1 Colección: 01-internacional Asunto principal: Epóxido Hidrolasas / Simulación de Dinámica Molecular Idioma: En Revista: Int J Biol Macromol Año: 2023 Tipo del documento: Article País de afiliación: China

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