"From molecular to clinic": The pivotal role of CDC42 in pathophysiology of human papilloma virus related cancers and a correlated sensitivity of afatinib.

Wei, Erdong; Li, Jiahua; Anand, Philipp; French, Lars E; Wattad, Adam; Clanner-Engelshofen, Benjamin; Reinholz, Markus

Wei, Erdong; Li, Jiahua; Anand, Philipp; French, Lars E; Wattad, Adam; Clanner-Engelshofen, Benjamin; Reinholz, Markus.

Afiliación

Wei E; Department of Dermatology and Allergy, University Hospital, Ludwig Maximilians University of Munich (LMU) Munich, Munich, Germany.
Li J; Department of Dermatology and Allergy, University Hospital, Ludwig Maximilians University of Munich (LMU) Munich, Munich, Germany.
Anand P; Department of Dermatology and Allergy, University Hospital, Ludwig Maximilians University of Munich (LMU) Munich, Munich, Germany.
French LE; Department of Dermatology and Allergy, University Hospital, Ludwig Maximilians University of Munich (LMU) Munich, Munich, Germany.
Wattad A; Dr. Phillip Frost Department of Dermatology & Cutaneous Surgery, Miller School of Medicine, University of Miami, Miami, United States.
Clanner-Engelshofen B; Department of Dermatology and Allergy, University Hospital, Ludwig Maximilians University of Munich (LMU) Munich, Munich, Germany.
Reinholz M; Department of Dermatology and Allergy, University Hospital, Ludwig Maximilians University of Munich (LMU) Munich, Munich, Germany.

Front Immunol ; 14: 1118458, 2023.

Article en En | MEDLINE | ID: mdl-36936942

Asunto(s)

Carcinoma de Células Escamosas; Infecciones por Papillomavirus; Proteína de Unión al GTP cdc42; Femenino; Humanos; Afatinib/farmacología; Afatinib/uso terapéutico; Carcinoma de Células Escamosas/genética; Carcinoma de Células Escamosas/virología; Receptores ErbB/genética; Receptores ErbB/metabolismo; GTP Fosfohidrolasas; Virus del Papiloma Humano; Simulación del Acoplamiento Molecular; Infecciones por Papillomavirus/genética; Proteína de Unión al GTP cdc42/genética; Proteína de Unión al GTP cdc42/metabolismo

Palabras clave

CDC42; DNA methylation; HPV-related cancers; afatinib; scRNA

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Texto completo: 1 Colección: 01-internacional Asunto principal: Carcinoma de Células Escamosas / Proteína de Unión al GTP cdc42 / Infecciones por Papillomavirus Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Female / Humans Idioma: En Revista: Front Immunol Año: 2023 Tipo del documento: Article País de afiliación: Alemania

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