Androgen receptor blockade resistance with enzalutamide in prostate cancer results in immunosuppressive alterations in the tumor immune microenvironment.

Xu, Pengfei; Yang, Joy C; Chen, Bo; Nip, Christopher; Van Dyke, Jonathan E; Zhang, Xiong; Chen, Hong-Wu; Evans, Christopher P; Murphy, William J; Liu, Chengfei

Xu, Pengfei; Yang, Joy C; Chen, Bo; Nip, Christopher; Van Dyke, Jonathan E; Zhang, Xiong; Chen, Hong-Wu; Evans, Christopher P; Murphy, William J; Liu, Chengfei.

Afiliación

Xu P; Department of Urologic Surgery, University of California Davis, Sacramento, California, USA.
Yang JC; Department of Urologic Surgery, University of California Davis, Sacramento, California, USA.
Chen B; Department of Urologic Surgery, University of California Davis, Sacramento, California, USA.
Nip C; Department of Urologic Surgery, University of California Davis, Sacramento, California, USA.
Van Dyke JE; Flow Cytometry Core, University of California Davis, Sacramento, California, USA.
Zhang X; Department of Biochemistry and Molecular Medicine, University of California Davis, Davis, California, USA.
Chen HW; Department of Biochemistry and Molecular Medicine, University of California Davis, Davis, California, USA.
Evans CP; University of California Davis Comprehensive Cancer Center, Sacramento, California, USA.
Murphy WJ; Department of Urologic Surgery, University of California Davis, Sacramento, California, USA.
Liu C; University of California Davis Comprehensive Cancer Center, Sacramento, California, USA.

J Immunother Cancer ; 11(5)2023 05.

Article en En | MEDLINE | ID: mdl-37147019

Asunto(s)

Neoplasias de la Próstata Resistentes a la Castración; Receptores Androgénicos; Animales; Humanos; Masculino; Ratones; Resistencia a Antineoplásicos; Inmunosupresores/uso terapéutico; Feniltiohidantoína/farmacología; Feniltiohidantoína/uso terapéutico; Neoplasias de la Próstata Resistentes a la Castración/tratamiento farmacológico; Neoplasias de la Próstata Resistentes a la Castración/patología; Receptores Androgénicos/genética; Receptores Androgénicos/metabolismo; Microambiente Tumoral

Palabras clave

Drug Therapy, Combination; Immune Evation; Programmed Cell Death 1 Receptor; Prostatic Neoplasms; Tumor Microenvironment

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Texto completo: 1 Colección: 01-internacional Asunto principal: Receptores Androgénicos / Neoplasias de la Próstata Resistentes a la Castración Límite: Animals / Humans / Male Idioma: En Revista: J Immunother Cancer Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos

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