Regional anesthesia is associated with improved metastasis free survival after surgical resection of bone sarcomas.
J Orthop Res
; 41(12): 2721-2729, 2023 12.
Article
en En
| MEDLINE
| ID: mdl-37151123
ABSTRACT
There is increasing evidence that perioperative factors, including type of anesthesia, may be an important consideration regarding oncological disease progression. Previous studies have suggested that regional anesthesia can improve oncological outcomes by reducing the surgical stress response that occurs during tumor resection surgery and that may promote metastatic progression. The purpose of this study is to provide the first robust investigation of the impact of adding regional anesthesia to general anesthesia on oncological outcomes following sarcoma resection. One hundred patients with bone sarcoma were retrospectively analyzed in this study. After adjusting for confounding variables such as age and grade of the tumor, patients with bone sarcoma receiving regional anesthesia in addition to general anesthesia during resection had improved metastasis free survival (multivariate hazard ratio of 0.47 and p = 0.034). Future studies are needed to confer the beneficial effect of regional anesthesia, and to further investigate the potential mechanism. Clinical significance:
The results from this study provide evidence that regional anesthesia may be advantageous in the setting of bone sarcoma resection surgery, reducing pain while also improving oncological outcomes and should be considered when clinically appropriate.Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Sarcoma
/
Neoplasias Óseas
/
Osteosarcoma
/
Anestesia de Conducción
Tipo de estudio:
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
J Orthop Res
Año:
2023
Tipo del documento:
Article
País de afiliación:
Estados Unidos