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A prognostic model for oral squamous cell carcinoma patients with type 2 diabetes mellitus.
Hu, Xin; Xiong, Haofeng; Huang, Shiying; Zeng, Liujun; Su, Tong.
Afiliación
  • Hu X; Department of Oral and Maxillofacial Surgery, Center of Stomatology, Xiangya Hospital, Central South University, Changsha, China; Research Center of Oral and Maxillofacial Tumor, Xiangya Hospital, Central South University, Changsha, China; Institute of Oral Precancerous Lesions, Central South Univer
  • Xiong H; Department of Oral and Maxillofacial Surgery, Center of Stomatology, Xiangya Hospital, Central South University, Changsha, China; Research Center of Oral and Maxillofacial Tumor, Xiangya Hospital, Central South University, Changsha, China; Institute of Oral Precancerous Lesions, Central South Univer
  • Huang S; Department of Oral and Maxillofacial Surgery, Center of Stomatology, Xiangya Hospital, Central South University, Changsha, China; Research Center of Oral and Maxillofacial Tumor, Xiangya Hospital, Central South University, Changsha, China; Institute of Oral Precancerous Lesions, Central South Univer
  • Zeng L; Department of Oral and Maxillofacial Surgery, Center of Stomatology, Xiangya Hospital, Central South University, Changsha, China; Research Center of Oral and Maxillofacial Tumor, Xiangya Hospital, Central South University, Changsha, China; Institute of Oral Precancerous Lesions, Central South Univer
  • Su T; Department of Oral and Maxillofacial Surgery, Center of Stomatology, Xiangya Hospital, Central South University, Changsha, China; Research Center of Oral and Maxillofacial Tumor, Xiangya Hospital, Central South University, Changsha, China; Institute of Oral Precancerous Lesions, Central South Univer
Arch Oral Biol ; 152: 105735, 2023 Aug.
Article en En | MEDLINE | ID: mdl-37244089
ABSTRACT

OBJECTIVE:

To build a prognostic model for oral squamous cell carcinoma patients with type 2 diabetes mellitus.

DESIGN:

Oral squamous cell carcinoma patients with type 2 diabetes mellitus in Xiangya Hospital were studied. Patients during January 2011 to January 2015 were included in training set (n = 146), and those during January 2017 to December 2020 were included in test set (n = 81). Univariate and multivariate Cox regressions were used to screen independent prognostic variables. Nomogram was used to show the model. C-index, internal bootstrap resampling and external validation were used to evaluate the model.

RESULTS:

Six independent prognostic factors (T stage, N stage, pathological grade, metformin use, sulfonylureas use, and fasting blood glucose) were screened from training set. Based on the six variables, nomogram was constructed to predict the prognosis of oral squamous cell carcinoma patients with type 2 diabetes mellitus. C-index value was 0.728, and result of internal bootstrap resampling showed better prediction efficiency for one-year survival. All patients were divided into two groups according to total points calculated based on the model. Group with low total points experienced better survival than that with high total points both in training set and test set.

CONCLUSIONS:

The model provides a relatively accurate method to predict the prognosis of oral squamous cell carcinoma patients with type 2 diabetes mellitus.
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Texto completo: 1 Colección: 01-internacional Asunto principal: Neoplasias de la Boca / Carcinoma de Células Escamosas / Diabetes Mellitus Tipo 2 / Neoplasias de Cabeza y Cuello Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Arch Oral Biol Año: 2023 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Asunto principal: Neoplasias de la Boca / Carcinoma de Células Escamosas / Diabetes Mellitus Tipo 2 / Neoplasias de Cabeza y Cuello Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Arch Oral Biol Año: 2023 Tipo del documento: Article