CaV3.2 (CACNA1H) in Primary Aldosteronism.
Handb Exp Pharmacol
; 279: 249-262, 2023.
Article
en En
| MEDLINE
| ID: mdl-37311830
ABSTRACT
Aldosterone is a steroid hormone produced in the zona glomerulosa (ZG) of the adrenal cortex. The most prominent function of aldosterone is the control of electrolyte homeostasis and blood pressure via the kidneys. The primary factors regulating aldosterone synthesis are the serum concentrations of angiotensin II and potassium. The T-type voltage-gated calcium channel CaV3.2 (encoded by CACNA1H) is an important component of electrical as well as intracellular calcium oscillations, which govern aldosterone production in the ZG. Excessive aldosterone production that is (partially) uncoupled from physiological stimuli leads to primary aldosteronism, the most common cause of secondary hypertension. Germline gain-of-function mutations in CACNA1H were identified in familial hyperaldosteronism, whereas somatic mutations are a rare cause of aldosterone-producing adenomas. In this review, we summarize these findings, put them in perspective, and highlight missing knowledge.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Canales de Calcio Tipo T
/
Hiperaldosteronismo
/
Hipertensión
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Handb Exp Pharmacol
Año:
2023
Tipo del documento:
Article
País de afiliación:
Alemania