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Discovery of a highly potent NPAS3 heterodimer inhibitor by covalently modifying ARNT.
Li, Peizhuo; Tian, Yucheng; Shang, Qinghong; Tang, Cailing; Hou, Zeng; Li, Yuanqing; Cao, Liyuan; Xue, Shengyu; Bian, Jinlei; Luo, Cheng; Wu, Dalei; Li, Zhiyu; Ding, Hong.
Afiliación
  • Li P; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.
  • Tian Y; Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
  • Shang Q; Helmholtz International Lab, State Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, China.
  • Tang C; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.
  • Hou Z; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310053, China.
  • Li Y; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.
  • Cao L; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
  • Xue S; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.
  • Bian J; Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
  • Luo C; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.
  • Wu D; Helmholtz International Lab, State Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, China. Electronic address: dlwu@sdu.edu.cn.
  • Li Z; Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China. Electronic address: zhiyuLi@cpu.edu.cn.
  • Ding H; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China. Electronic address: hding@simm.ac.cn.
Bioorg Chem ; 139: 106676, 2023 10.
Article en En | MEDLINE | ID: mdl-37352720
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Texto completo: 1 Colección: 01-internacional Asunto principal: Receptores de Hidrocarburo de Aril / Translocador Nuclear del Receptor de Aril Hidrocarburo Tipo de estudio: Prognostic_studies Idioma: En Revista: Bioorg Chem Año: 2023 Tipo del documento: Article País de afiliación: China
Texto completo
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Texto completo: 1 Colección: 01-internacional Asunto principal: Receptores de Hidrocarburo de Aril / Translocador Nuclear del Receptor de Aril Hidrocarburo Tipo de estudio: Prognostic_studies Idioma: En Revista: Bioorg Chem Año: 2023 Tipo del documento: Article País de afiliación: China