Impact of genetic variations in the WNT family members and RUNX2 on dental and skeletal maturation: a cross-sectional study.
Head Face Med
; 19(1): 26, 2023 Jul 03.
Article
en En
| MEDLINE
| ID: mdl-37400934
ABSTRACT
BACKGROUND:
This study evaluated if genetic variations in the WNT family members and RUNX2 are associated with craniofacial maturation, investigating dental and skeletal maturity in children and teenagers.METHODS:
Radiographs from pre-orthodontic treatment of Brazilian patients (7 to 17 years-old) were used to assess dental (panoramic radiographs) and skeletal maturity (cephalometric radiographs). The chronological age (CA) was calculated based on the date of birth and the time the radiographs were performed. For the dental maturity analysis, the Demirjian (1973) method was used and a delta [dental age - chronological age (DA-CA)] was calculated. For the skeletal maturity analysis, the Baccetti et al. (2005) method was used and the patients were classified as "delayed skeletal maturation", "advanced skeletal maturation" or "normal skeletal maturation". DNA isolated from buccal cells was used for genotyping of two genetic variations in WNT family genes rs708111 (G > A) in WNT3A and rs1533767 (G > A) in WNT11; and two genetic variations in RUNX2 rs1200425 (G > A) and rs59983488 (G > T). A statistical analysis was performed and values of p < 0.05 indicated a significant difference.RESULTS:
There were no associations between dental maturity and genotypes (p > 0.05). In the skeletal maturity analysis, the allele A in the rs708111 (WNT3A) was statistically more frequent in patients with delayed skeletal maturation (Prevalence Ratio = 1.6; 95% Confidence Interval = 1.00 to 2.54; p-value = 0.042).CONCLUSIONS:
The rs708111 in the WNT3A gene impacts on skeletal maturation.Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Subunidad alfa 1 del Factor de Unión al Sitio Principal
/
Proteína Wnt3
/
Mucosa Bucal
Tipo de estudio:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Child
/
Humans
Idioma:
En
Revista:
Head Face Med
Asunto de la revista:
MEDICINA
/
ODONTOLOGIA
/
ORTOPEDIA
Año:
2023
Tipo del documento:
Article
País de afiliación:
Brasil