Uncovering NOTCH1 as a Promising Target in the Treatment of <i>MLL</i>-Rearranged Leukemia.

Fischer, Jacqueline; Erkner, Estelle; Fitzel, Rahel; Radszuweit, Pia; Keppeler, Hildegard; Korkmaz, Fulya; Roti, Giovanni; Lengerke, Claudia; Schneidawind, Dominik; Schneidawind, Corina

Uncovering NOTCH1 as a Promising Target in the Treatment of MLL-Rearranged Leukemia.

Fischer, Jacqueline; Erkner, Estelle; Fitzel, Rahel; Radszuweit, Pia; Keppeler, Hildegard; Korkmaz, Fulya; Roti, Giovanni; Lengerke, Claudia; Schneidawind, Dominik; Schneidawind, Corina.

Afiliación

Fischer J; Department of Medicine II, University Hospital Tuebingen, Eberhard Karls University, 72076 Tuebingen, Germany.
Erkner E; Department of Medicine II, University Hospital Tuebingen, Eberhard Karls University, 72076 Tuebingen, Germany.
Fitzel R; Department of Medicine II, University Hospital Tuebingen, Eberhard Karls University, 72076 Tuebingen, Germany.
Radszuweit P; Department of Medicine II, University Hospital Tuebingen, Eberhard Karls University, 72076 Tuebingen, Germany.
Keppeler H; Department of Medicine II, University Hospital Tuebingen, Eberhard Karls University, 72076 Tuebingen, Germany.
Korkmaz F; Department of Medicine II, University Hospital Tuebingen, Eberhard Karls University, 72076 Tuebingen, Germany.
Roti G; Department of Medicine and Surgery, University of Parma, 43121 Parma, Italy.
Lengerke C; Department of Medicine II, University Hospital Tuebingen, Eberhard Karls University, 72076 Tuebingen, Germany.
Schneidawind D; Department of Medicine II, University Hospital Tuebingen, Eberhard Karls University, 72076 Tuebingen, Germany.
Schneidawind C; Department of Medical Oncology and Hematology, University Hospital Zurich, 8091 Zurich, Switzerland.

Int J Mol Sci ; 24(19)2023 Sep 23.

Article en En | MEDLINE | ID: mdl-37833915

Asunto(s)

Leucemia Mieloide Aguda; Receptor Notch1; Humanos; Puntos de Control del Ciclo Celular/genética; Citarabina/uso terapéutico; N-Metiltransferasa de Histona-Lisina/genética; Leucemia Mieloide Aguda/genética; Leucemia Mieloide Aguda/terapia; Proteína de la Leucemia Mieloide-Linfoide/genética; Proteína de la Leucemia Mieloide-Linfoide/metabolismo; Proteínas de Fusión Oncogénica/genética; Receptor Notch1/genética

Palabras clave

CRISPR/Cas9; MLL-rearranged leukemia; NOTCH1; SERCA inhibitor; targeted therapy

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Texto completo: 1 Colección: 01-internacional Asunto principal: Leucemia Mieloide Aguda / Receptor Notch1 Límite: Humans Idioma: En Revista: Int J Mol Sci Año: 2023 Tipo del documento: Article País de afiliación: Alemania

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