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Clostridioides difficile utilizes siderophores as an iron source and FhuDBGC contributes to ferrichrome uptake.
Hastie, Jessica L; Carmichael, Hannah L; Werner, Bailey M; Dunbar, Kristin E; Carlson, Paul E.
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  • Hastie JL; Food and Drug Administration, Center for Biologics Evaluation and Research, Office of Vaccines Research and Review, Division of Bacterial Parasitic and Allergenic Products, Laboratory of Mucosal Pathogens and Cellular Immunology, Silver Spring, Maryland, USA.
  • Carmichael HL; Food and Drug Administration, Center for Biologics Evaluation and Research, Office of Vaccines Research and Review, Division of Bacterial Parasitic and Allergenic Products, Laboratory of Mucosal Pathogens and Cellular Immunology, Silver Spring, Maryland, USA.
  • Werner BM; Food and Drug Administration, Center for Biologics Evaluation and Research, Office of Vaccines Research and Review, Division of Bacterial Parasitic and Allergenic Products, Laboratory of Mucosal Pathogens and Cellular Immunology, Silver Spring, Maryland, USA.
  • Dunbar KE; Food and Drug Administration, Center for Biologics Evaluation and Research, Office of Vaccines Research and Review, Division of Bacterial Parasitic and Allergenic Products, Laboratory of Mucosal Pathogens and Cellular Immunology, Silver Spring, Maryland, USA.
  • Carlson PE; Food and Drug Administration, Center for Biologics Evaluation and Research, Office of Vaccines Research and Review, Division of Bacterial Parasitic and Allergenic Products, Laboratory of Mucosal Pathogens and Cellular Immunology, Silver Spring, Maryland, USA.
J Bacteriol ; 205(12): e0032423, 2023 12 19.
Article en En | MEDLINE | ID: mdl-37971230
ABSTRACT
IMPORTANCE This study is the first example of C. difficile growing with siderophores as the sole iron source and describes the characterization of the ferric hydroxamate uptake ABC transporter (FhuDBGC). This transporter shows specificity to the siderophore ferrichrome. While not required for pathogenesis, this transporter highlights the redundancy in iron acquisition mechanisms that C. difficile uses to compete for iron during an infection.
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Texto completo: 1 Colección: 01-internacional Asunto principal: Clostridioides difficile / Sideróforos Idioma: En Revista: J Bacteriol Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Asunto principal: Clostridioides difficile / Sideróforos Idioma: En Revista: J Bacteriol Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos