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Clinical application of cytokine-induced killer (CIK) cell therapy in colorectal cancer: Current strategies and future challenges.
Ying Li, Celine Man; Li, Runhao; Drew, Paul; Price, Timothy; Smith, Eric; Maddern, Guy J; Tomita, Yoko; Fenix, Kevin.
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  • Ying Li CM; Department of Surgery, Adelaide Medical School, The University of Adelaide, Adelaide, SA 5005, Australia; Basil Hetzel Institute for Translational Health Research, The Queen Elizabeth Hospital, Woodville, SA 5011, Australia.
  • Li R; Basil Hetzel Institute for Translational Health Research, The Queen Elizabeth Hospital, Woodville, SA 5011, Australia; Medical Oncology, The Queen Elizabeth Hospital and The University of Adelaide, Woodville, SA 5011, Australia.
  • Drew P; Department of Surgery, Adelaide Medical School, The University of Adelaide, Adelaide, SA 5005, Australia; Basil Hetzel Institute for Translational Health Research, The Queen Elizabeth Hospital, Woodville, SA 5011, Australia.
  • Price T; Basil Hetzel Institute for Translational Health Research, The Queen Elizabeth Hospital, Woodville, SA 5011, Australia; Medical Oncology, The Queen Elizabeth Hospital and The University of Adelaide, Woodville, SA 5011, Australia.
  • Smith E; Department of Surgery, Adelaide Medical School, The University of Adelaide, Adelaide, SA 5005, Australia; Basil Hetzel Institute for Translational Health Research, The Queen Elizabeth Hospital, Woodville, SA 5011, Australia; Medical Oncology, The Queen Elizabeth Hospital and The University of Adelai
  • Maddern GJ; Department of Surgery, Adelaide Medical School, The University of Adelaide, Adelaide, SA 5005, Australia; Basil Hetzel Institute for Translational Health Research, The Queen Elizabeth Hospital, Woodville, SA 5011, Australia.
  • Tomita Y; Basil Hetzel Institute for Translational Health Research, The Queen Elizabeth Hospital, Woodville, SA 5011, Australia; Medical Oncology, The Queen Elizabeth Hospital and The University of Adelaide, Woodville, SA 5011, Australia.
  • Fenix K; Department of Surgery, Adelaide Medical School, The University of Adelaide, Adelaide, SA 5005, Australia; Basil Hetzel Institute for Translational Health Research, The Queen Elizabeth Hospital, Woodville, SA 5011, Australia. Electronic address: kevin.fenix@adelaide.edu.au.
Cancer Treat Rev ; 122: 102665, 2024 Jan.
Article en En | MEDLINE | ID: mdl-38091655
ABSTRACT
Colorectal cancer (CRC) remains a significant global health burden and is the second leading cause of cancer-related death. Cytokine induced killer (CIK) cell therapy is an immunotherapy which has the potential to meet this need. Clinical trials of CIK cell therapy for the management of CRC have reported improved clinical outcomes. However, production and delivery protocols varied significantly, and many studies were reported only in Chinese language journals. Here we present the most comprehensive review of the clinical CIK cell therapy trials for CRC management to date. We accessed both English and Chinese language clinical studies, and summarise how CIK cell therapy has been implemented, from manufacturing to patient delivery. We discuss current challenges that impede wider adoption of CIK cell therapy in CRC management.
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Texto completo: 1 Colección: 01-internacional Asunto principal: Neoplasias Colorrectales / Inmunoterapia Adoptiva Límite: Humans Idioma: En Revista: Cancer Treat Rev Año: 2024 Tipo del documento: Article País de afiliación: Australia
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Texto completo: 1 Colección: 01-internacional Asunto principal: Neoplasias Colorrectales / Inmunoterapia Adoptiva Límite: Humans Idioma: En Revista: Cancer Treat Rev Año: 2024 Tipo del documento: Article País de afiliación: Australia