Identification of risk factors for disseminated cryptococcosis in non-hiv patients: a retrospective analysis.
Eur J Med Res
; 28(1): 612, 2023 Dec 19.
Article
en En
| MEDLINE
| ID: mdl-38115055
ABSTRACT
OBJECTIVE:
This study aimed to investigate the potential risk factors associated with disseminated cryptococcosis in HIV-negative individuals.METHODS:
A total of 106 HIV-negative patients with cryptococcal disease were enrolled. The observation group consisted of patients with disseminated cryptococcosis (DC), whereas the control groups included patients with pulmonary cryptococcosis (PC) and cryptococcal meningitis (CM). Univariate and multivariate logistic regression algorithms were used to explore the significant clinical and laboratory characteristics that affect the progression of cryptococcal infections. Finally, receiver operating characteristics (ROC) curves are applied to assess the diagnostic value of identified risk factors.LE Kindly check the edit made in the title.I agreeRESULTS:
Of the 106 patients, 57 were diagnosed with pulmonary cryptococcosis, 22 with cryptococcal meningitis, and 27 with disseminated cryptococcosis. The logistic regression equation included five variables diabetes, decompensated liver cirrhosis, long-term use of immunosuppressive agents, decreased serum albumin level, and elevated plasma cytokine IL-10 level. The ROC curves showed that albumin (AUC > 0.7), IL-10 (AUC > 0.7) and decompensated liver cirrhosis (AUC > 0.6) have relatively high diagnostic capacity in predicting the progression of Cryptococcus.CONCLUSION:
This study identified elevated IL-10 levels as an independent risk factor for developing disseminated cryptococcosis in the control groups. Furthermore, decompensated liver cirrhosis and decreased serum albumin independently affected the progression of cryptococcosis in the CM and PC groups, respectively.Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Infecciones por VIH
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Meningitis Criptocócica
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Criptococosis
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Cryptococcus
Límite:
Humans
Idioma:
En
Revista:
Eur J Med Res
Asunto de la revista:
MEDICINA
Año:
2023
Tipo del documento:
Article