Methotrexate level discrepancy post-glucarpidase: A pediatric case series and review of literature.
Pediatr Blood Cancer
; 71(3): e30831, 2024 Mar.
Article
en En
| MEDLINE
| ID: mdl-38149827
ABSTRACT
Methotrexate is a common component of pediatric oncology treatment and delayed clearance increases risk of significant toxicities. Glucarpidase is indicated for patients with toxic plasma methotrexate concentrations with renal toxicity. Laboratory interference with immunoassay measurement post-glucarpidase administration is well established, with current product labeling indicating this persists for 48 h. However, recent experience in pediatric patients supports this discrepancy persists beyond 48 h. Three cases experienced delayed methotrexate clearance and received glucarpidase with subsequent measurement of methotrexate levels by liquid chromatography tandem mass spectrometry (LC-MS/MS) and/or immunoassay. Within this case series, discrepancies between LC-MS/MS and immunoassay levels persisted significantly longer than 48 h.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Metotrexato
/
Antimetabolitos Antineoplásicos
Límite:
Child
/
Humans
Idioma:
En
Revista:
Pediatr Blood Cancer
/
Pediatr. blood cancer
/
Pediatric blood & cancer
Asunto de la revista:
HEMATOLOGIA
/
NEOPLASIAS
/
PEDIATRIA
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos