MCP-5 suppresses osteoclast differentiation through Ccr5 upregulation.
J Cell Physiol
; 239(2): e31171, 2024 Feb.
Article
en En
| MEDLINE
| ID: mdl-38214098
ABSTRACT
Human monocyte chemoattractant protein-1 (MCP-1) in mice has two orthologs, MCP-1 and MCP-5. MCP-1, which is highly expressed in osteoclasts rather than in osteoclast precursor cells, is an important factor in osteoclast differentiation. However, the roles of MCP-5 in osteoclasts are completely unknown. In this study, contrary to MCP-1, MCP-5 was downregulated during receptor activator of nuclear factor kappa B ligand (RANKL)-induced osteoclast differentiation and was considered an inhibitory factor in osteoclast differentiation. The inhibitory role of MCP-5 in osteoclast differentiation was closely related to the increase in Ccr5 expression and the inhibition of IκB degradation by RANKL. Transgenic mice expressing MCP-5 controlled by Mx-1 promoter exhibited an increased bone mass because of a decrease in osteoclasts. This result strongly supported that MCP-5 negatively regulated osteoclast differentiation. MCP-5 also prevented severe bone loss caused by RANKL.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Osteoclastos
/
Glicoproteínas de Membrana
/
Diferenciación Celular
/
Proteínas Quimioatrayentes de Monocitos
Límite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
J Cell Physiol
/
J. cell. physiol
/
Journal of cellular physiology
Año:
2024
Tipo del documento:
Article