A single locus determines praziquantel response in Schistosoma mansoni.
Antimicrob Agents Chemother
; 68(3): e0143223, 2024 Mar 06.
Article
en En
| MEDLINE
| ID: mdl-38289079
ABSTRACT
We previously performed a genome-wide association study (GWAS) to identify the genetic basis of praziquantel (PZQ) response in schistosomes, identifying two quantitative trait loci situated on chromosomes 2 and 3. We reanalyzed this GWAS using the latest (version 10) genome assembly showing that a single locus on chromosome 3, rather than two independent loci, determines drug response. These results reveal that PZQ response is monogenic and demonstrates the importance of high-quality genomic information.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Esquistosomiasis mansoni
/
Antihelmínticos
Límite:
Animals
Idioma:
En
Revista:
Antimicrob Agents Chemother
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos