Novel BRAF N581S mutation in mantle cell lymphoma.

Hariharan, Nisha; Bedi, Davsheen; Choi, Michael Y; Wang, Huan-You; Heyman, Benjamin M.

Afiliación

Hariharan N; Division of Hematology/Oncology Department of Medicine University of California San Diego La Jolla California USA.
Bedi D; Department of Pathology University of California San Diego La Jolla California USA.
Choi MY; Division of Hematology/Oncology Department of Medicine University of California San Diego La Jolla California USA.
Wang HY; Department of Pathology University of California San Diego La Jolla California USA.
Heyman BM; Division of Regenerative Medicine Department of Medicine University of California San Diego La Jolla California USA.

EJHaem ; 5(1): 247-250, 2024 Feb.

Article en En | MEDLINE | ID: mdl-38406519

ABSTRACT

BRAF mutations are associated with a small number of hematologic malignancies, including hairy cell leukemia and histiocytic disorders. In addition, BRAF mutations have also been detected in low frequency in other B-cell lymphomas, such as chronic lymphocytic leukemia and diffuse large B-cell lymphoma, but never in mantle cell lymphoma (MCL). We present a case of a 69-year-old female with classic MCL harboring a BRAFN581S mutation. To our knowledge, this is the first reported case of any BRAF mutation in MCL.

Palabras clave

BRAF mutation; mantle cell lymphoma; novel