Early delivery of human umbilical cord mesenchymal stem cells improves healing in a rat model of Achilles tendinopathy.
Regen Med
; 19(2): 93-102, 2024 02.
Article
en En
| MEDLINE
| ID: mdl-38415316
ABSTRACT
Objective:
This study aimed to explore the efficacy and optimal delivery time of human umbilical cord mesenchymal stem cells (hUC-MSCs) in treating collagenase-induced Achilles tendinopathy.Methods:
Achilles tendinopathy in rats at early or advanced stages was induced by injecting collagenase I into bilateral Achilles tendons. A total of 28 injured rats were injected with a hUC-MSC solution or normal saline into bilateral tendons twice and sampled after 4 weeks for histological staining, gene expression analysis, transmission electron microscope assay and biomechanical testing analysis.Results:
The results revealed better histological performance and a larger collagen fiber diameter in the MSC group. mRNA expression of TNF-α, IL-1ß and MMP-3 was lower after MSC transplantation. Early MSC delivery promoted collagen I and TIMP-3 synthesis, and strengthened tendon toughness.Conclusion:
hUC-MSCs demonstrated a therapeutic effect in treating collagenase-induced Achilles tendinopathy, particularly in the early stage of tendinopathy.Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Tendón Calcáneo
/
Trasplante de Células Madre Mesenquimatosas
/
Tendinopatía
/
Células Madre Mesenquimatosas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Regen Med
/
Regenerative medicine (Online)
Año:
2024
Tipo del documento:
Article
País de afiliación:
China