Unsymmetrical Benzothieno-Fused BODIPYs as Efficient NIR Heavy-Atom-Free Photosensitizers.
J Org Chem
; 89(7): 4826-4839, 2024 04 05.
Article
en En
| MEDLINE
| ID: mdl-38471124
ABSTRACT
Heavy-atom-free photosensitizers are potentially suitable for use in photodynamic therapy (PDT). In this contribution, a new family of unsymmetrical benzothieno-fused BODIPYs with reactive oxygen efficiency up to 50% in air-saturated toluene was reported. Their efficient intersystem crossing (ISC) resulted in the generation of both 1O2 and O2-⢠under irradiation. More importantly, the PDT efficacy of a respective 4-methoxystyryl-modified benzothieno-fused BODIPY in living cells exhibited an extremely high phototoxicity with an ultralow IC50 value of 2.78 nM. The results revealed that the incorporation of an electron-donating group at the α-position of the unsymmetrical benzothieno-fused BODIPY platform might be an effective approach for developing long-wavelength absorbing heavy-atom-free photosensitizers for precision cancer therapy.
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Fotoquimioterapia
/
Compuestos de Boro
/
Fármacos Fotosensibilizantes
Idioma:
En
Revista:
J Org Chem
/
J. org. chem
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Journal of organic chemistry
Año:
2024
Tipo del documento:
Article
País de afiliación:
China