HPV-associated cervicovaginal microbiome and host metabolome characteristics.
BMC Microbiol
; 24(1): 94, 2024 Mar 22.
Article
en En
| MEDLINE
| ID: mdl-38519882
ABSTRACT
BACKGROUND:
Cervicovaginal microbiome plays an important role in the persistence of HPV infection and subsequent disease development. However, cervicovaginal microbiota varied cross populations with different habits and regions. Identification of population-specific biomarkers from cervicovaginal microbiota and host metabolome axis may support early detection or surveillance of HPV-induced cervical disease at all sites. Therefore, in the present study, to identify HPV-specific biomarkers, cervicovaginal secretion and serum samples from HPV-infected patients (HPV group, n = 25) and normal controls (normal group, n = 17) in Xichang, China were collected for microbiome (16S rRNA gene sequencing) and metabolome (UHPLC-MS/MS) analysis, respectively.RESULTS:
The results showed that key altered metabolites of 9,10-DiHOME, α-linolenic acid, ethylparaben, glycocholic acid, pipecolic acid, and 9,12,13-trihydroxy-10(E),15(Z)-octadecadienoic acid, correlating with Sneathia (Sneathia_amnii), Lactobacillus (Lactobacillus_iners), Atopobium, Mycoplasma, and Gardnerella, may be potential biomarkers of HPV infection.CONCLUSION:
The results of current study would help to reveal the association of changes in cervicovaginal microbiota and serum metabolome with HPV infections.Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Infecciones por Papillomavirus
/
Microbiota
Límite:
Female
/
Humans
Idioma:
En
Revista:
BMC Microbiol
Asunto de la revista:
MICROBIOLOGIA
Año:
2024
Tipo del documento:
Article
País de afiliación:
China