Multifunctional Hydrogel of Recombinant Humanized Collagen Loaded with MSCs and MnO2 Accelerates Chronic Diabetic Wound Healing.
ACS Biomater Sci Eng
; 10(5): 3188-3202, 2024 05 13.
Article
en En
| MEDLINE
| ID: mdl-38592024
ABSTRACT
Chronic wound repair is a clinical treatment challenge. The development of multifunctional hydrogels is of great significance in the key aspects of treating chronic wounds, including reducing oxidative stress, promoting angiogenesis, and improving the natural remodeling of extracellular matrix and immune regulation. In this study, we prepared a composite hydrogel, sodium alginate (SA)@MnO2/recombinant humanized collagen III (RHC)/mesenchymal stem cells (MSCs), composed of SA, MnO2 nanoparticles, RHC, and MSCs. The hydrogel has high mechanical properties and good biocompatibility. In vitro, SA@MnO2/RHC/MSCs hydrogel effectively enhanced the formation of intricate tubular structures and angiogenesis and showed synergistic effects on cell proliferation and migration. In vivo, the SA@MnO2/RHC/MSCs hydrogel enhanced diabetes wound healing, rapid re-epithelization, favorable collagen deposition, and abundant wound angiogenesis. These findings demonstrated that the combined effects of SA, MnO2, RHC, and MSCs synergistically accelerate healing, resulting in a reduced healing time. These observed healing effects demonstrated the potential of this multifunctional hydrogel to transform chronic wound care and improve patient outcomes.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Óxidos
/
Cicatrización de Heridas
/
Compuestos de Manganeso
/
Hidrogeles
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Células Madre Mesenquimatosas
Límite:
Animals
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Humans
/
Male
Idioma:
En
Revista:
ACS Biomater Sci Eng
/
ACS biomater. sci. eng
/
ACS biomaterials science & engineering
Año:
2024
Tipo del documento:
Article
País de afiliación:
China