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A taste alteration-related scale assesses megestrol to improve chemotherapy-induced anorexia.
Wang, Lihong; Tan, Yaling; Yao, Lan; He, Daqiang.
Afiliación
  • Wang L; Department of Medical Oncology Ward 3, Affiliated Hangzhou Cancer Hospital, Hangzhou, 310002, Zhejiang, China.
  • Tan Y; Department of Thoracic Oncology, Affiliated Hangzhou Cancer Hospital, Hangzhou, 310002, Zhejiang, China.
  • Yao L; Department of Medical Oncology Ward 3, Affiliated Hangzhou Cancer Hospital, Hangzhou, 310002, Zhejiang, China. 231546074@qq.com.
  • He D; Department of Laboratory Medicine, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, 310006, Zhejiang, China. daqiang318@163.com.
Support Care Cancer ; 32(5): 300, 2024 Apr 22.
Article en En | MEDLINE | ID: mdl-38644409
ABSTRACT

PURPOSE:

We evaluated the efficacy of megestrol in improving chemotherapy-related anorexia by analyzing the related scales of taste alteration.

METHODS:

We conducted the current study on a group of advanced patients with cancer with two or more chemotherapy cycles. The chemotherapy-induced taste alteration scale (CiTAs) scale helped assess the megestrol effects on basic taste perception, aversive taste changes, unpleasant symptoms, and associated concerns. Furthermore, the Short Nutritional Assessment Questionnaire scale (SNAQ) helped measure the impact of megestrol on malnutrition likelihood in patients experiencing chemotherapy-induced anorexia. The World Health Organization Quality of Life (WHOQOL)-BREF Scale was used to evaluate the quality of life of participants, producing scores related to physical health, psychological well-being, environmental factors, and social relationships.

RESULTS:

The CiTAs scale assessment indicated that administering megestrol significantly enhanced taste perception among advanced patients with cancer undergoing chemotherapy. Notably, the megestrol group patients showed significantly higher Short Nutritional Assessment Questionnaire (SNAQ) scores than the control group. The megestrol group patients also exhibited higher physiological (PHYS) scores than their control group counterparts. However, this distinction was not statistically significant. The study findings indicate that patients who received megestrol demonstrated significantly higher scores in psychological (PSYCH) and environmental(ENVIR) domains than the control group. Furthermore, megestrol administration was associated with significantly elevated SOCIL and ENVIR levels in patients.

CONCLUSION:

The proficient efficacy evaluation of megestrol in enhancing appetite, mitigating malnutrition likelihood, and improving the quality of life of chemotherapy-induced anorexic patients can be achieved through taste-related scales.
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Texto completo: 1 Colección: 01-internacional Asunto principal: Calidad de Vida / Anorexia / Neoplasias / Antineoplásicos Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Support Care Cancer Asunto de la revista: NEOPLASIAS / SERVICOS DE SAUDE Año: 2024 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Colección: 01-internacional Asunto principal: Calidad de Vida / Anorexia / Neoplasias / Antineoplásicos Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Support Care Cancer Asunto de la revista: NEOPLASIAS / SERVICOS DE SAUDE Año: 2024 Tipo del documento: Article País de afiliación: China