Mendelian randomization analyses reveal no genetic causal effects of major adipokines on systemic lupus erythematosus.
PLoS One
; 19(5): e0301699, 2024.
Article
en En
| MEDLINE
| ID: mdl-38805491
ABSTRACT
Epidemiological studies have shown that the levels of serum adipokine such as leptin and resistin are associated with the risk of developing systemic lupus erythematosus (SLE). Nevertheless, whether either leptin or resistin has causal impacts on the risk of SLE is still unknown. In this study, two-sample univariable MR analyses and multivariable MR analysis were performed to explore the causal relationships between adipokines and SLE. Additionally, the potential causal effects of SLE on major adipokines were evaluated using reverse MR analyses. The results of inverse-variance weighted (IVW), weighted median, weighted mode and MRâEgger methods concordantly supported that major adipokines have no causal effects on the risk of SLE. In the multivariable MR IVW analysis with leptin and resistin as covariates, neither leptin (odds ratio (OR) = 3.093, P = 0.067) nor resistin (OR = 0.477, P = 0.311) was identified as an independent risk factor for SLE, which is in line with the univariable MR results. In conclusion, our analyses revealed no evidence to support that these three major adipokines are risk factors for SLE.
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Resistina
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Adipoquinas
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Análisis de la Aleatorización Mendeliana
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Lupus Eritematoso Sistémico
Límite:
Humans
Idioma:
En
Revista:
PLoS ONE (Online)
/
PLoS One
/
PLos ONE
Asunto de la revista:
CIENCIA
/
MEDICINA
Año:
2024
Tipo del documento:
Article