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Treatment-emergent cefiderocol resistance in carbapenem-resistant Acinetobacter baumannii is associated with insertion sequence ISAba36 in the siderophore receptor pirA.
Huang, En; Thompson, Rebekah N; Moon, Sun Hee; Keck, Jacob M; Lowry, Michael S; Melero, Joe; Jun, Se-Ran; Rosenbaum, Eric R; Dare, Ryan K.
Afiliación
  • Huang E; Department of Environmental Health Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
  • Thompson RN; Department of Internal Medicine, Division of Infectious Diseases, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
  • Moon SH; Department of Environmental Health Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
  • Keck JM; Department of Pharmacy Practice, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
  • Lowry MS; Department of Internal Medicine, Division of Infectious Diseases, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
  • Melero J; Department of Pathology and Laboratory Services, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
  • Jun S-R; Department of Biomedical Informatics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
  • Rosenbaum ER; Department of Pathology and Laboratory Services, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
  • Dare RK; Department of Internal Medicine, Division of Infectious Diseases, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Antimicrob Agents Chemother ; 68(7): e0029024, 2024 Jul 09.
Article en En | MEDLINE | ID: mdl-38809000
ABSTRACT
We report the emergence of cefiderocol resistance in a blaOXA-72 carbapenem-resistant Acinetobacter baumannii isolate from a sacral decubitus ulcer. Cefiderocol was initially used; however, a newly approved sulbactam-durlobactam therapy with source control and flap coverage was successful in treating the infection. Laboratory investigation revealed cefiderocol resistance mediated by ISAba36 insertion into the siderophore receptor pirA.
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Texto completo: 1 Colección: 01-internacional Asunto principal: Infecciones por Acinetobacter / Pruebas de Sensibilidad Microbiana / Carbapenémicos / Cefalosporinas / Acinetobacter baumannii / Cefiderocol / Antibacterianos Límite: Humans / Male Idioma: En Revista: Antimicrob Agents Chemother Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Asunto principal: Infecciones por Acinetobacter / Pruebas de Sensibilidad Microbiana / Carbapenémicos / Cefalosporinas / Acinetobacter baumannii / Cefiderocol / Antibacterianos Límite: Humans / Male Idioma: En Revista: Antimicrob Agents Chemother Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos