A chiral trimethyl lock based on the vicinal disubstituent effect: prolonged release of camptothecin into cancer cells.
Chem Commun (Camb)
; 60(51): 6524-6527, 2024 Jun 20.
Article
en En
| MEDLINE
| ID: mdl-38836387
ABSTRACT
Synthesis and in vitro testing of a prodrug designed for the controlled delivery of the anticancer drug camptothecin within pancreatic cancer cells are reported. Our study reveals a non-conventional pharmacokinetic release characterized by an exponential pattern before reaching the half-life (t1/2) and a linear pattern thereafter. The release mechanism was triggered either by hydrolytic enzymes and/or by the acid microenvironment of cancer cells.
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Camptotecina
/
Profármacos
Límite:
Humans
Idioma:
En
Revista:
Chem Commun (Camb)
Asunto de la revista:
QUIMICA
Año:
2024
Tipo del documento:
Article
País de afiliación:
Italia