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Excess non-COVID-19-related mortality among inflammatory bowel disease decedents during the COVID-19 pandemic.
Rotondo-Trivette, Sarah; He, Xin-Yuan; Samaan, Jamil S; Lv, Fan; Truong, Emily; Juels, Michaela; Nguyen, Anthony; Gao, Xu; Zu, Jian; Yeo, Yee Hui; Ji, Fan-Pu; Melmed, Gil Y.
Afiliación
  • Rotondo-Trivette S; Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, United States.
  • He XY; Department of Infectious Disease, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, Shaanxi Province, China.
  • Samaan JS; Karsh Division of Gastroenterology and Hepatology Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, United States.
  • Lv F; School of Mathematics and Statistics, Xi'an Jiaotong University, Xi'an 710049, Shaanxi Province, China.
  • Truong E; Karsh Division of Gastroenterology and Hepatology Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, United States.
  • Juels M; David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, United States.
  • Nguyen A; David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, United States.
  • Gao X; Department of Infectious Disease, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, Shaanxi Province, China.
  • Zu J; Division of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, Shaanxi Province, China.
  • Yeo YH; School of Mathematics and Statistics, Xi'an Jiaotong University, Xi'an 710049, Shaanxi Province, China.
  • Ji FP; Karsh Division of Gastroenterology and Hepatology Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, United States.
  • Melmed GY; Department of Infectious Disease, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, Shaanxi Province, China.
World J Gastroenterol ; 30(20): 2677-2688, 2024 May 28.
Article en En | MEDLINE | ID: mdl-38855149
ABSTRACT

BACKGROUND:

The coronavirus disease 2019 (COVID-19) pandemic disrupted healthcare in the United States.

AIM:

To investigate COVID-19-related and non-COVID-19-related death and characteristics associated with excess death among inflammatory bowel disease (IBD) decedents.

METHODS:

We performed a register-based study using data from the National Vital Statistics System, which reports death data from over 99% of the United States population, from January 1, 2006 through December 31, 2021. IBD-related deaths among adults 25 years and older were stratified by age, sex, race/ethnicity, place of death, and primary cause of death. Predicted and actual age-standardized mortality rates (ASMRs) per 100000 persons were compared.

RESULTS:

49782 IBD-related deaths occurred during the study period. Non-COVID-19-related deaths increased by 13.14% in 2020 and 18.12% in 2021 [2020 ASMR 1.55 actual vs 1.37 predicted, 95% confidence interval (CI) 1.26-1.49; 2021 ASMR 1.63 actual vs 1.38 predicted, 95%CI 1.26-1.49]. In 2020, non-COVID-19-related mortality increased by 17.65% in ulcerative colitis (UC) patients between the ages of 25 and 65 and 36.36% in non-Hispanic black (NHB) Crohn's disease (CD) patients. During the pandemic, deaths at home or on arrival and at medical facilities as well as deaths due to neoplasms also increased.

CONCLUSION:

IBD patients suffered excess non-COVID-19-related death during the pandemic. Excess death was associated with younger age among UC patients, and with NHB race among CD patients. Increased death at home or on arrival and due to neoplasms suggests that delayed presentation and difficulty accessing healthcare may have led to increased IBD mortality.
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Texto completo: 1 Colección: 01-internacional Asunto principal: Enfermedades Inflamatorias del Intestino / Causas de Muerte / COVID-19 Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: World J Gastroenterol / World j. gastroenterol / World journal of gastroenterology Asunto de la revista: GASTROENTEROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Asunto principal: Enfermedades Inflamatorias del Intestino / Causas de Muerte / COVID-19 Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: World J Gastroenterol / World j. gastroenterol / World journal of gastroenterology Asunto de la revista: GASTROENTEROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos