The carrier function and inhibition effect on benign prostatic hyperplasia of a glucan from Epimedium brevicornu Maxim.
Carbohydr Polym
; 340: 122316, 2024 Sep 15.
Article
en En
| MEDLINE
| ID: mdl-38858029
ABSTRACT
Epimedium, a traditional Chinese medicine commonly used as a dietary supplement, contains polysaccharides and flavonoids as its main bioactive ingredients. In this study, a neutral homogeneous polysaccharide (EPSN-1) was isolated from Epimedium brevicornu Maxim. EPSN-1 was identified as a glucan with a backbone of â4)-α-D-Glcp-(1â, branched units comprised α-D-Glcp-(1â6)-α-D-Glcp-(1â, ß-D-Glcp-(1â6)-ß-D-Glcp-(1â and α-D-Glcp-(1â connected to the C6 position of backbone. The conformation of EPSN-1 in aqueous solution indicated its potential to form nanoparticles. This paper aims to investigate the carrier and pharmacodynamic activity of EPSN-1. The findings demonstrated that, on the one hand, EPSN-1, as a functional ingredient, may load Icariin (ICA) through non-covalent interactions, improving its biopharmaceutical properties such as solubility and stability, thereby improving its intestinal absorption. Additionally, as an effective ingredient, EPSN-1 could help maintain the balance of the intestinal environment by increasing the abundance of Parabacteroides, Lachnospiraceae UGG-001, Anaeroplasma, and Eubacterium xylanophilum group, while decreasing the abundance of Allobaculum, Blautia, and Adlercreutzia. Overall, this dual action of EPSN-1 sheds light on the potential applications of natural polysaccharides, highlighting their dual role as carriers and contributors to biological activity.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Hiperplasia Prostática
/
Flavonoides
/
Epimedium
/
Glucanos
Límite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
Carbohydr Polym
/
Carbohydrate polymers
Año:
2024
Tipo del documento:
Article