The BLV-miRNAs pathway of BLV inhibits the expression of Lactoferrin, Lactoperoxidase, Alpha-lactalbumin and Beta-lactoglobulin proteins.
Vet Microbiol
; 295: 110153, 2024 Aug.
Article
en En
| MEDLINE
| ID: mdl-38889618
ABSTRACT
Bovine leukemia virus (BLV) is a widespread virus that decreases milk production and quality in dairy cows. As crucial components of BLV, BLV-encoded microRNAs (BLV-miRNAs) affect BLV replication and may impact the synthesis of Lactoferrin (LTF), Lactoperoxidase (LPO), Alpha-lactalbumin (alpha-LA), and Beta-lactoglobulin (beta-LG). In this study, we investigated the targeting relationship between BLV-miRNAs and LTF, LPO, alpha-LA, and beta-LG in cow's milk. Additionally, we investigated the possible mechanisms by which BLV reduces milk quality. The results showed that cow's milk had significantly lower levels of LTF, LPO, and alpha-LA proteins in BLV-positive cows than in BLV-negative cows. BLV-â³miRNAs (miRNA-deleted BLV) enhanced the reduction of LPO, alpha-LA, and beta-LG protein levels caused by BLV infection. Multiple BLV-miRNAs have binding sites with LTF and LPO mRNA; however, only BLV-miR-B1-5â¯P has a targeting relationship with LPO mRNA. The results revealed that BLV-miR-B1-5â¯P inhibits LPO protein expression by targeting LPO mRNA. However, BLV does not directly regulate the expression of LTF, alpha-LA, or beta-LG proteins through BLV-miRNAs.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Virus de la Leucemia Bovina
/
MicroARNs
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Leche
/
Lactalbúmina
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Lactoferrina
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Lactoglobulinas
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Lactoperoxidasa
Límite:
Animals
Idioma:
En
Revista:
Vet Microbiol
/
Vet. microbiol
/
Veterinary microbiology
Año:
2024
Tipo del documento:
Article