IL-4 polymorphisms (rs2227284, rs2243267, and rs2243270) are associated with reduced risk of rheumatoid arthritis.
Autoimmunity
; 57(1): 2364684, 2024 Dec.
Article
en En
| MEDLINE
| ID: mdl-38902969
ABSTRACT
BACKGROUND:
Rheumatoid arthritis (RA) is a chronic autoimmune disease, and understanding its genetic and molecular basis is crucial for early diagnosis, treatment, and prevention.OBJECTIVE:
This study aims to explore the association between IL-4 polymorphisms (rs2227284, rs2243267, rs2243270, and rs2243283) and RA risk.METHODS:
The four IL-4 polymorphisms were genotyped in 493 RA patients and 493 healthy controls using Agena MassARRAY. Logistic regression analysis calculated odds ratio (OR) and 95% confidence interval (CI) to estimate the relationship between IL-4 polymorphisms and RA risk.RESULTS:
Overall analysis revealed that rs2243267 (GG vs. CC OR = 0.26, FDR-p = .032; Recessive OR = 0.27, FDR-p = .048) and rs2243270 (AA vs. GG OR = 0.26, FDR-p = .024; Recessive OR = 0.27, FDR-p = .024) were associated with a decreased risk of RA. Stratified analysis indicated that rs2243267 and rs2243270 were correlated with reduced RA risk in female, smoking, BMI <24, and drinking population; rs2227284 was associated with a decreased RA risk in BMI <24 and drinking population. Moreover, rs2243267 and rs2243270 were significantly associated with reduced ACPA positivity.CONCLUSIONS:
Our findings suggest that IL-4 polymorphisms (rs2227284, rs2243267, and rs2243270) act as protective factors for RA in the Chinese Han population.Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Artritis Reumatoide
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Interleucina-4
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Predisposición Genética a la Enfermedad
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Polimorfismo de Nucleótido Simple
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Genotipo
Límite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Autoimmunity
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
2024
Tipo del documento:
Article
País de afiliación:
China