Hyperguanyes A and B, two new PPAPs from the branches and leaves of <i>Hypericum perforatum</i> L. with anti-cholinesterase activities.

Li, Yanan; Wang, Kunling; Liu, Rui; Jiang, Jian; Zheng, Donghai

Hyperguanyes A and B, two new PPAPs from the branches and leaves of Hypericum perforatum L. with anti-cholinesterase activities.

Li, Yanan; Wang, Kunling; Liu, Rui; Jiang, Jian; Zheng, Donghai.

Afiliación

Li Y; Department of Traditional Chinese Medicine, People's Hospital of Dongxihu District, Wuhan, Hubei, P.R. China.
Wang K; Department of Pharmacy, People's Hospital of Dongxihu District, Wuhan, Hubei, P.R. China.
Liu R; Department of Neurology, The First Hospital of Yulin, Yulin, Shanxi, P.R. China.
Jiang J; Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, Hubei, P.R. China.
Zheng D; Department of Traditional Chinese Medicine, People's Hospital of Dongxihu District, Wuhan, Hubei, P.R. China.

Nat Prod Res ; : 1-8, 2024 Jun 25.

Article en En | MEDLINE | ID: mdl-38916532

ABSTRACT

ABSTRACT

Two new polycyclic polyprenylated acylphloroglucinols, hyperguanyes A and B (1-2) together with eight known compounds (3-10), were isolated from Hypericum perforatum L. Their structures were determined by using comprehensive spectroscopic techniques and quantum chemical calculation. The in vitro anti-cholinesterase activity of all compounds were studied. Among them, compounds 1-4, 8 and 9 exhibited anti-AchE and anti-BchE effects with IC50 ranging from 0.34 ± 0.04 to 15.68 ± 0.54 µM.

Palabras clave

Hypericum perforatum L; PPAPs; anti-cholinesterase activity; hyperguanyes a and B; wogonin

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google