Rituximab for rheumatoid arthritis-related interstitial lung disease: A systematic review and meta-analysis.
Arch Rheumatol
; 39(2): 317-329, 2024 Jun.
Article
en En
| MEDLINE
| ID: mdl-38933731
ABSTRACT
Objectives:
This systematic review and meta-analysis aimed at summarizing the evidence of efficacy and safety of rituximab in rheumatoid arthritis-related interstitial lung disease (RA-ILD). Materials andmethods:
PubMed and Embase databases were searched until June 22, 2022, to identify studies on RA-ILD treated with rituximab, confined to predefined inclusion and exclusion criteria. A systematic review and meta-analysis were performed on the included studies to assess the overall stabilization or improvement in ILD, changes in percent-predicted (%-predicted) forced vital capacity (FVC), and %-predicted diffusion capacity of lungs for carbon monoxide (DLCO) following rituximab therapy.Results:
A total of 15 studies (4 prospective and 11 retrospective studies) were included, with a total of 314 patients. There were 105 (60.7%) females out of 173 subjects for whom sex details were available from seven studies. The overall pooled proportion of patients with stabilization or improvement in ILD was 0.88 [95% confidence interval (CI) 0.76-0.96, p=0.02]. Rituximab improved FVC from baseline by 7.50% (95% CI 1.35-13.65; p=0.02, fixed effect). Similarly, rituximab improved DLCO by 6.39% (95% CI 1.366-14.43; p=0.12, random-effect). Two retrospective studies reported reduced mortality with rituximab therapy compared to tumor necrosis factor-alpha inhibitors.Conclusion:
Treatment with rituximab in RA-ILD was associated with a significant improvement in %-predicted FVC, as well as stabilization or improvement in ILD after one year of treatment.
Texto completo:
1
Colección:
01-internacional
Idioma:
En
Revista:
Arch Rheumatol
Año:
2024
Tipo del documento:
Article
País de afiliación:
India