Atypical hemolytic uremic syndrome during induction chemotherapy in neuroblastoma, a rare phenomenon or common congenital predisposition?
Pediatr Blood Cancer
; 71(9): e31175, 2024 Sep.
Article
en En
| MEDLINE
| ID: mdl-38961591
ABSTRACT
Atypical hemolytic uremic syndrome (aHUS) is a complement-mediated thrombotic microangiopathy sometimes associated with germline variants in genes of the complement system. Clinical findings of microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury arise due to aberrant complement protein activation in the circulation. A 13-month-old boy with metastatic neuroblastoma (NB) developed aHUS during his first cycle of induction chemotherapy with germline testing revealing a complement factor H (CFH) gene mutation, currently classified as a variant of uncertain significance (VUS). Now he is in disease remission after successful complement blockade therapy, thus highlighting a unique presentation of aHUS in a patient with newly diagnosed NB.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Quimioterapia de Inducción
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Síndrome Hemolítico Urémico Atípico
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Neuroblastoma
Límite:
Humans
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Infant
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Male
Idioma:
En
Revista:
Pediatr Blood Cancer
/
Pediatr. blood cancer
/
Pediatric blood & cancer
Asunto de la revista:
HEMATOLOGIA
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NEOPLASIAS
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PEDIATRIA
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos