Hedgehog pathway and cancer: A new area (Review).
Oncol Rep
; 52(3)2024 09.
Article
en En
| MEDLINE
| ID: mdl-38994763
ABSTRACT
In years of research on classical pathways, the composition, information transmission mechanism, crosstalk with other pathways, and physiological and pathological effects of hedgehog (HH) pathway have been gradually clarified. HH also plays a critical role in tumor formation and development. According to the update of interpretation of tumor phenotypes, the latest relevant studies have been sorted out, to explore the specific mechanism of HH pathway in regulating different tumor phenotypes through gene mutation and signal regulation. The drugs and natural ingredients involved in regulating HH pathway were also reviewed; five approved drugs and drugs under research exert efficacy by blocking HH pathway, and at least 22 natural components have potential to treat tumors by HH pathway. Nevertheless, there is a deficiency of existing studies. The present review confirmed the great potential of HH pathway in future cancer treatment with factual basis.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Transducción de Señal
/
Proteínas Hedgehog
/
Neoplasias
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Oncol Rep
/
Oncol. rep
/
Oncology reports
Asunto de la revista:
NEOPLASIAS
Año:
2024
Tipo del documento:
Article