Advances in H2O2-supplying materials for tumor therapy: synthesis, classification, mechanisms, and applications.
Biomater Sci
; 12(16): 4083-4102, 2024 Aug 06.
Article
en En
| MEDLINE
| ID: mdl-39010783
ABSTRACT
Hydrogen peroxide (H2O2) as a reactive oxygen species produced by cellular metabolism can be used in antitumor therapy. However, the concentration of intracellular H2O2 limits its application. Some materials could enhance the concentration of intracellular H2O2 to strengthen antitumor therapy. In this review, the recent advances in H2O2-supplying materials in terms of promoting intracellular H2O2 production and exogenous H2O2 supply are summarized. Then the mechanism of H2O2-supplying materials for tumor therapy is discussed from three aspects reconstruction of the tumor hypoxia microenvironment, enhancement of oxidative stress, and the intrinsic anti-tumor ability of H2O2-supplying materials. In addition, the application of H2O2-supplying materials for tumor therapy is discussed. Finally, the future of H2O2-supplying materials is presented. This review aims to provide a novel idea for the application of H2O2-supplying materials in tumor therapy.
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Microambiente Tumoral
/
Peróxido de Hidrógeno
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Neoplasias
Límite:
Animals
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Humans
Idioma:
En
Revista:
Biomater Sci
Año:
2024
Tipo del documento:
Article