Introduction of one-view tomosynthesis in population-based mammography screening: Impact on detection rate, interval cancer rate and false-positive rate.
J Med Screen
; : 9691413241262259, 2024 Jul 25.
Article
en En
| MEDLINE
| ID: mdl-39053450
ABSTRACT
OBJECTIVE:
To assess performance endpoints of a combination of digital breast tomosynthesis (DBT) and full-field digital mammography (FFDM) compared with FFDM only in breast cancer screening. MATERIALS ANDMETHODS:
This was a prospective population-based screening study, including eligible (50-69 years) women attending the Capital Region Mammography Screening Program in Denmark. All attending women were offered FFDM. A subgroup was consecutively allocated to a screening room with DBT. All FFDM and DBT underwent independent double reading, and all women were followed up for 2 years after screening date or until next screening date, whichever came first.RESULTS:
6353 DBT + FFDM and 395 835 FFDM were included in the analysis and were undertaken in 196 267 women in the period from 1 November 2012 to 12 December 2018. Addition of DBT increased sensitivity 89.9% (95% confidence interval (CI) 81.0-95.5) for DBT + FFDM and 70.1% (95% CI 68.6-71.6) for FFDM only, p < 0.001. Specificity remained similar 98.2% (95% CI 97.9-98.5) for DBT + FFDM and 98.3% (95% CI 98.2-98.3) for FFDM only, p = 0.9. Screen-detected cancer rate increased statistically significantly 11.18/1000 for DBT + FFDM and 6.49/1000 for FFDM only, p < 0.001. False-positive rate was unchanged 1.75% for DBT + FFDM and 1.73% for FFDM only, p = 0.9. Positive predictive value for recall was 39.0% (95% CI 31.9-46.5) for DBT + FFDM and 27.3% (95% CI 26.4-28.2), for FFDM only, p < 0.0005. The interval cancer rate decreased 1.26/1000 for DBT + FFDM and 2.76/1000 for FFDM only, p = 0.02.CONCLUSION:
DBT + FFDM yielded a statistically significant increase in cancer detection and program sensitivity.
Texto completo:
1
Colección:
01-internacional
Idioma:
En
Revista:
J Med Screen
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J. med. screen
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Journal of medical screening
Asunto de la revista:
EPIDEMIOLOGIA
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SAUDE PUBLICA
Año:
2024
Tipo del documento:
Article
País de afiliación:
Dinamarca