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Intravesical Gemcitabine and Docetaxel Therapy for BCG-Naïve Patients: A Promising Approach to Non-Muscle Invasive Bladder Cancer.
Bakula, Mirko; Hudolin, Tvrtko; Knezevic, Nikola; Zimak, Zoran; Andelic, Jerko; Juric, Ilija; Gamulin, Marija; Gnjidic, Milena; Kastelan, Zeljko.
Afiliación
  • Bakula M; Department of Urology, University Hospital Centre Zagreb, Kispaticeva 12, 10000 Zagreb, Croatia.
  • Hudolin T; School of Medicine, University of Zagreb, Salata 3, 10000 Zagreb, Croatia.
  • Knezevic N; Department of Urology, University Hospital Centre Zagreb, Kispaticeva 12, 10000 Zagreb, Croatia.
  • Zimak Z; School of Medicine, University of Zagreb, Salata 3, 10000 Zagreb, Croatia.
  • Andelic J; Department of Urology, University Hospital Centre Zagreb, Kispaticeva 12, 10000 Zagreb, Croatia.
  • Juric I; School of Medicine, University of Zagreb, Salata 3, 10000 Zagreb, Croatia.
  • Gamulin M; Department of Urology, University Hospital Centre Zagreb, Kispaticeva 12, 10000 Zagreb, Croatia.
  • Gnjidic M; Department of Urology, University Hospital Centre Zagreb, Kispaticeva 12, 10000 Zagreb, Croatia.
  • Kastelan Z; Department of Urology, University Hospital Centre Zagreb, Kispaticeva 12, 10000 Zagreb, Croatia.
Life (Basel) ; 14(7)2024 Jun 22.
Article en En | MEDLINE | ID: mdl-39063544
ABSTRACT
Bacillus Calmette-Guérin (BCG) therapy for patients with non-muscle invasive bladder cancer (NMIBC) faces limitations in efficacy and significant side effects, aggravated by a recent global shortage. In this prospective clinical study, we report the outcomes of sequential intravesical administration of gemcitabine and docetaxel (Gem/Doce) as a first-line treatment for BCG-naïve patients with high-risk NMIBC (HR NMIBC). From October 2019 until April 2022, we enrolled 52 patients and followed the treatment protocol set forth by the University of Iowa. Follow-up assessments were conducted every 3 months. In this cohort, 25 (48.1%) patients were diagnosed with high-grade T1 (T1HG) bladder cancer, 10 (19.2%) patients had carcinoma in situ (CIS), and 17 (32.7%) patients had a combination of T1HG+CIS. The median time to first recurrence in the T1HG, CIS, and T1HG+CIS groups was 11, 10.5, and 8.8 months, respectively. The recurrence-free survival was 98.1%, 94.2%, and 80.8% at 6, 9, and 12 months, respectively. The rate of progression-free survival was 100%, 98.1%, and 92.3% at 6, 9, and 12 months, respectively. We demonstrated the safety and efficacy of Gem/Doce therapy in BCG-naïve patients with HR NMIBC during a one-year follow-up. Further research with extended follow-ups, as well as direct comparisons of Gem/Doce with other anticancer agents, is essential.
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Texto completo: 1 Colección: 01-internacional Idioma: En Revista: Life (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Croacia

Texto completo: 1 Colección: 01-internacional Idioma: En Revista: Life (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Croacia