Hormone receptor-positive early breast cancer in young women: A comprehensive review.
Cancer Treat Rev
; 129: 102804, 2024 Sep.
Article
en En
| MEDLINE
| ID: mdl-39084152
ABSTRACT
The incidence of breast cancer in ≤ 40 yr-old women (YWBC) has been steadily increasing in recent decades. Although this group of patients represents less than 10 % of all newly diagnosed BC cases it encompasses a significant burden of disease. Usually underrepresented in clinical trials, YWBCs are also characterized by late diagnoses and poorly differentiated, aggressive-subtype disease, partly explaining its poor prognosis along with a high recurrence risk, and high mortality rates. On the other hand, YWBC treatment poses unique challenges such as preservation of fertility, and long-term toxicity and adverse events. Herein, we summarize the current evidence in hormone receptor-positive YWBC including specific risk factors, clinicopathologic and genomic features, and available evidence on response to chemotherapy and endocrine therapy. Overall, we advocate for a more comprehensive multidisciplinary healthcare model to improve the outcomes and the quality of life of this subset of younger patients.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Neoplasias de la Mama
Límite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Cancer Treat Rev
/
Cancer treat. rev
/
Cancer treatment reviews
Año:
2024
Tipo del documento:
Article