Physicochemical properties and in vitro release of formononetin nano-particles by ultrasonic probe-assisted precipitation in four polar organic solvents.
Food Chem
; 461: 140918, 2024 Dec 15.
Article
en En
| MEDLINE
| ID: mdl-39181045
ABSTRACT
Although formononetin has a considerable biological activity, its therapeutic use is limited by its low solubility. Formononetin was dissolved in ethanol, methanol, N, N-dimethylformamide (DMF), and dimethyl sulfoxide (DMSO) in this investigation, the antisolvent precipitation procedure with the assistance of an external ultrasonic probe was used to manufacture the formononetin nano-particles. The ideal parameters for response surface BBD optimization are as follows feed volume flow rate of 6 mL/min; ultrasonic power of 860 W; and liquid-liquid ratio of 112.5. The formononetin nano-particles have a smaller particle diameter than raw sample; the lowest size can be as small as (329 ± 1.99) nm, which is 45 times smaller than raw. An in vitro digestion test using a solution that simulated intestinal solution revealed that the release rate of the nano-particle was 1.75 times than that of the raw formononetin. The formononetin nano-particles generated by the aforementioned four solvents have the following order of diameter ethanol > methanol > DMF > DMSO. This study provided a technical reference for the functional food components in deep processing.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Tamaño de la Partícula
/
Solventes
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Nanopartículas
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Isoflavonas
Idioma:
En
Revista:
Food Chem
Año:
2024
Tipo del documento:
Article