Virus receptors: implications for pathogenesis and the design of antiviral agents.
Clin Microbiol Rev
; 8(2): 293-315, 1995 Apr.
Article
en En
| MEDLINE
| ID: mdl-7621403
ABSTRACT
A virus initiates infection by attaching to its specific receptor on the surface of a susceptible host cell. This prepares the way for the virus to enter the cell. Consequently, the expression of the receptor on specific cells and tissues of the host is a major determinant of the route of entry of the virus into the host and of the patterns of virus spread and pathogenesis in the host. This review emphasizes the virus-receptor interactions of human immunodeficiency virus, the rhinoviruses, the herpesviruses, and the coronaviruses. These interactions are often found to be complex and dynamic, involving multiple sites or factors on both the virus and the host cell. Also, the receptor may play an important role in virus entry per se in addition to its role in virus binding. In the cases of human immunodeficiency virus and the rhinoviruses, ingenious approaches to therapeutic strategies based on inhibiting virus attachment and entry are under development and in clinical trials.
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Antivirales
/
Receptores Virales
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Clin Microbiol Rev
Asunto de la revista:
MICROBIOLOGIA
Año:
1995
Tipo del documento:
Article
País de afiliación:
Estados Unidos