Tumor necrosis factor-alpha in the female reproductive tract.
Proc Soc Exp Biol Med
; 209(4): 325-42, 1995 Sep.
Article
en En
| MEDLINE
| ID: mdl-7638240
ABSTRACT
Tumor necrosis factor-alpha (TNF), originally identified as an inflammation-associated cytokine, is synthesized throughout the female reproductive tract as well as in placentas and embryos. Development, female sex steroid hormones, and lipopolysaccharide influence expression of this gene. The functions of TNF may be determined in part by differential expression of the two species of TNF receptors, both of which seem to be regulated by female sex steroid hormones. Evidence has accumulated that supports a role for this potent, pleiotropic cytokine in autocrine and paracrine processes central to reproduction, including gamete and follicle development, steroidogenesis, uterine cyclicity, placental differentiation, development of the embryo, and parturition.
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Colección:
01-internacional
Asunto principal:
Ovario
/
Reproducción
/
Factor de Necrosis Tumoral alfa
/
Genitales Femeninos
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Proc Soc Exp Biol Med
Año:
1995
Tipo del documento:
Article
País de afiliación:
Estados Unidos