Azolophenanthridines as antineoplastic agents.
Farmaco
; 50(6): 365-8, 1995 Jun.
Article
en En
| MEDLINE
| ID: mdl-7669175
ABSTRACT
Pyrrolo-, pyrazolo- and triazolo-phenanthridines were synthetized by using a Pschorrtype cyclization reaction or an intramolecular cyclization of arylnitrenium ions. By using these synthetic methods several azolo-phenanthridines, variously functionalized either in the azolo ring and in the phenanthridine moiety, were prepared. The title compounds, tested against murine leukemia cell lines, sensible and multidrug resistant, showed moderate activity with IC50 in the range 5-50 microM.
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Colección:
01-internacional
Asunto principal:
Fenantridinas
/
Antineoplásicos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Farmaco
Asunto de la revista:
FARMACOLOGIA
/
QUIMICA
Año:
1995
Tipo del documento:
Article
País de afiliación:
Italia