Definition of a pharmacophore for the metabotropic glutamate receptors negatively linked to adenylyl cyclase.
Bioorg Med Chem
; 1(4): 259-65, 1993 Oct.
Article
en En
| MEDLINE
| ID: mdl-7915955
ABSTRACT
(2S,3S,4S)-alpha-Carboxycyclopropylglycine (L-CCG I) and trans-1-amino-(1S,3R)-cyclopentanedicarboxylic acid ((1S,3R)-ACPD), partially constrained L-glutamate analogs known to be agonists at the metabotropic glutamate receptors (mGluRs) adenylyl cyclase coupled, have been submitted to conformational analysis and the data obtained utilized to define a pharmacophore which takes into account the location of hydrogen bonding donating sites of the receptor. This pharmacophore has been utilized to define the agonist mGluRs decreases cAMP bioactive conformation of L-Glu.
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Colección:
01-internacional
Asunto principal:
Adenilil Ciclasas
/
Receptores de Glutamato Metabotrópico
/
Glutamatos
Límite:
Animals
Idioma:
En
Revista:
Bioorg Med Chem
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
1993
Tipo del documento:
Article
País de afiliación:
Italia