Duration of action of intranasal atropine on methacholine-induced nasal secretions.
Arch Otolaryngol Head Neck Surg
; 122(3): 321-3, 1996 Mar.
Article
en En
| MEDLINE
| ID: mdl-8607961
ABSTRACT
OBJECTIVE:
To evaluate the duration of the inhibitory action of intranasal atropine on the secretory response to nasal challenge with methacholine.DESIGN:
Double-blind, placebo-controlled, four-way crossover trial.SUBJECTS:
Twelve volunteers with perennial allergic rhinitis.INTERVENTIONS:
Subjects were treated intranasally with placebo or 100, 200, and 400 micrograms of atropine in each nostril. They were then challenged 30 minutes after administration of the nasal spray and hourly for 6 hours with 0.19 mg of methacholine. The weight of nasal secretions generated by methacholine challenge served as an indicator of the secretory response. The nasal challenges and the collection of nasal secretions were performed using filter paper disks.RESULTS:
After placebo treatment, the response to methacholine was similar at each time point. In contrast, all doses of atropine significantly reduced the response to methacholine stimulation at the 30-minute, 1-hour, and 2-hour time points.CONCLUSIONS:
Our data show that the anticholinergic activity of intranasal atropine lasts at least 2 hours with no significant difference in the duration of inhibitory action between the doses used. The results suggest that intranasal atropine could become a therapeutic modality for patients in whom glandular hypersecretion is a major symptom.
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Colección:
01-internacional
Asunto principal:
Atropina
/
Rinitis Alérgica Perenne
/
Antagonistas Muscarínicos
/
Pruebas de Provocación Nasal
Tipo de estudio:
Clinical_trials
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Arch Otolaryngol Head Neck Surg
Asunto de la revista:
OTORRINOLARINGOLOGIA
Año:
1996
Tipo del documento:
Article
País de afiliación:
Estados Unidos