Liver involvement in white patients with sickle-cell disease.
Arch Pediatr Adolesc Med
; 150(11): 1177-80, 1996 Nov.
Article
en En
| MEDLINE
| ID: mdl-8904859
ABSTRACT
BACKGROUND:
Liver involvement and cholelithiasis are common complications of sickle-cell disease. The incidence of clinically evident hepatic damage reported in the literature for black people varies from 15% to 30%, while no data are reported for white people.OBJECTIVE:
To evaluate the liver involvement in 40 patients with homozygous sickle cell anemia (the beta 5 beta 5 form of sickle-cell disease) and 102 patients with double-heterozygous hemoglobin S and beta-thalassemia (65 with the beta 5 beta 0th and 37 with the beta 5 beta +th form of sickle-cell disease).SETTING:
The Department of Pediatric Hematology and Oncology, University of Catania, Catania, Italy. PATIENTS Outpatients with sickle-cell disease.RESULTS:
We found that, in our patients, liver disease seems to be clinically irrelevant only 2 of the 142 patients examined had notable alterations in hepatic function. Cholelithiasis was found in 42.1% of the subjects with the beta 5 beta 5 form of sickle-cell disease and in 26.8% of the subjects with the beta 5 beta th form. Age-related analysis revealed a greater incidence of cholelithiasis during the first years of life in the patients with the beta 5 beta 5 form of the disease than in patients with the beta 5 beta th form.CONCLUSION:
Our data showed that liver involvement in sickle-cell disease is clinically irrelevant, reflecting the fact that the clinical expression of sickle-cell disease in Sicilian patients is moderate.
Buscar en Google
Colección:
01-internacional
Asunto principal:
Anemia de Células Falciformes
/
Hepatopatías
Tipo de estudio:
Etiology_studies
Límite:
Adolescent
/
Adult
/
Child
/
Child, preschool
/
Humans
/
Infant
/
Middle aged
Idioma:
En
Revista:
Arch Pediatr Adolesc Med
Asunto de la revista:
PEDIATRIA
Año:
1996
Tipo del documento:
Article
País de afiliación:
Italia