Plasmalogen and anionic phospholipid dependence of the cardiac sarcolemmal sodium-calcium exchanger.
FEBS Lett
; 394(1): 99-102, 1996 Sep 23.
Article
en En
| MEDLINE
| ID: mdl-8925938
ABSTRACT
Although plasmalogens are the predominant phospholipids of cardiac sarcolemma, their physiological role has not been forthcoming. Since the cardiac sarcolemmal sodium-calcium exchanger has been proposed to be regulated by anionic phospholipids, the roles of plasmalogens and anionic phospholipids as regulators of the sodium-calcium exchanger were explored. Reconstituted sodium-calcium exchange activity in plasmalogen-containing proteoliposomes was 10-fold higher than that in control proteoliposomes comprised of only diacyl phospholipids. Additionally, exchange activity in plasmalogen-containing proteoliposomes was regulated by anionic phospholipids. Thus, plasmalogens provide a critical lipid environment in which anionic phospholipids serve as boundary lipids for the regulation of the trans-sarcolemmal sodium-calcium exchanger.
Buscar en Google
Colección:
01-internacional
Asunto principal:
Fosfolípidos
/
Sarcolema
/
Plasmalógenos
/
Proteínas Portadoras
/
Miocardio
Límite:
Animals
Idioma:
En
Revista:
FEBS Lett
Año:
1996
Tipo del documento:
Article
País de afiliación:
Estados Unidos