Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizer.
Cell
; 88(6): 747-56, 1997 Mar 21.
Article
en En
| MEDLINE
| ID: mdl-9118218
ABSTRACT
Frzb-1 is a secreted protein containing a domain similar to the putative Wnt-binding region of the frizzled family of transmembrane receptors. Frzb-1 is widely expressed in adult mammalian tissues. In the Xenopus gastrula, it is expressed and regulated as a typical Spemann organizer component. Injection of frzb-1 mRNA blocks expression of XMyoD mRNA and leads to embryos with enlarged heads and shortened trunks. Frzb-1 antagonizes the effects of Xwnt-8 ectopic expression in a non-cell-autonomous manner. Cultured cells transfected with a membrane-tethered form of Wnt-1 bind epitope-tagged Frzb-1 in the 10(-10) M range. The results strengthen the view that the Spemann organizer is a source of secreted inhibitory factors.
Texto completo:
1
Colección:
01-internacional
Asunto principal:
Xenopus
/
Glicoproteínas
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Proteínas
/
Proteínas Proto-Oncogénicas
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Proteínas de Pez Cebra
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Mitógenos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Cell
Año:
1997
Tipo del documento:
Article
País de afiliación:
Estados Unidos