Topography and biological role of integrins in human skin.
Microsc Res Tech
; 38(4): 353-60, 1997 Aug 15.
Article
en En
| MEDLINE
| ID: mdl-9297685
ABSTRACT
We report the topography of integrins in the human epidermis and in cultured human keratinocytes. Both in situ and in vitro beta 1 integrins are exposed at the cell-cell adhesion interface while beta 4 is located on the basal membrane in contact with the basal lamina. Such defined sorting identifies discrete cell membrane domains that may be involved in defining, building up, and maintaining epithelial cell polarity. The distribution of integrins is deeply altered in hyperproliferative states like those occurring in several experimental conditions and in epidermal diseases.
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Colección:
01-internacional
Asunto principal:
Piel
/
Integrinas
Límite:
Humans
Idioma:
En
Revista:
Microsc Res Tech
Asunto de la revista:
DIAGNOSTICO POR IMAGEM
Año:
1997
Tipo del documento:
Article
País de afiliación:
Italia