Endoclips as novel fiducial markers in trimodality bladder-preserving therapy of muscle-invasive bladder carcinoma: feasibility and patient outcomes
Int. braz. j. urol
; 47(1): 93-99, Jan.-Feb. 2021. tab, graf
Artigo
em Inglês
| LILACS
| ID: biblio-1134320
Biblioteca responsável:
BR1.1
ABSTRACT
ABSTRACT Hypothesis:
Endoclip can be used as fiducial marker in urology.Objective:
To assess the feasibility, cost effectiveness and reliability of endoclips as novel fiducial markers in precision radiotherapy, as part of a trimodality bladder-preserving treatment (TBPT) of muscle-invasive bladder carcinoma. Materials andMethods:
This retrospective study was performed at Weifang People's Hospital (Weifang, China) from January 2015 to June 2018. A total of 15 patients underwent TBPT. Endoclips were applied to healthy edges of the resected bladder wall as novel fiducial markers. Radio-sensitizing chemotherapy and routine precision radiotherapy were given. The number and position of the endoclips during radiotherapy sessions were monitored. Complications and tumor recurrence were analyzed.Results:
The mean age (±standard deviation) of the patients was 67±10 years (range 46-79). There were 3 females and 12 males. Forty-nine endoclips were applied in all patients (3.3±0.8). The tumor was completely visibly resected in all patients. The number of endoclips remained the same through the planned last radiotherapy session (3.3±0.8), i.e., none were lost. All endoclips were removed after the last radiotherapy session. The average number of follow-up months was 38.9±13.2 (range 11-52). There were no procedure-related complications at discharge or follow-up. At one-year, overall recurrence-free survival was 93.3%. Two patients had recurrences at 18 months and 10 months after TBPT, respectively, and salvage radical cystectomy was performed with no further recurrences. Another patient died due to metastasis 9 months after the completion of therapy.Conclusions:
Endoclips are reliable, safe and cost-effective as novel fiducial markers in precision-radiotherapy post-TBPT.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Temas:
Geral
/
Tipos de Câncer
/
Outros Tipos
/
Tratamento
/
Radioterapia
Base de dados:
LILACS
Assunto principal:
Neoplasias da Bexiga Urinária
/
Carcinoma
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Idoso
/
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Int. braz. j. urol
Assunto da revista:
Urologia
Ano de publicação:
2021
Tipo de documento:
Artigo
País de afiliação:
China
/
Paquistão
Instituição/País de afiliação:
Combined Military Hospital/PK
/
Shandong University/CN
/
Weifang People´s Hospital/CN
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