Influence of rs6667202 SNP on Interleukin-10 levels in the gingival fluid of patients with periodontitis grade C
Braz. j. oral sci
; 20: e211654, jan.-dez. 2021. ilus
Article
em En
| BBO, LILACS
| ID: biblio-1254524
Biblioteca responsável:
BR218.1
ABSTRACT
Grade C periodontitis in youngers is characterized by a severe form of periodontitis, and IL10 rs6667202 single nucleotide polymorphism (SNP) has been described as an important feature in this disease etiology. Aim:
This study aimed to evaluate, in vivo, the functionality of IL10 rs6667202 SNP on IL-10 gingival fluid levels.Methods:
Thirty patients with Perio4C were selected, 15 with the IL10 AA genotype (rs6667202) and 15 with AC/CC genotypes. The gingival fluid was collected from two sites with probing depth ≥ 7 mm and bleeding on probing, and two healthy sites. The IL-10 concentration was determined by Luminex/MAGpix platform.Results:
In deep pockets, the IL10 AA genotype presented a lower concentration of IL-10 when compared with AC or CC genotypes (p<0.05). In shallow pockets, no difference between groups was seen (p>0.05).Conclusion:
IL10 rs6667202 SNP decreases the production of IL-10 in crevicular fluid, potentially affecting this disease progressionPalavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Periodontite Agressiva
/
Interleucina-10
/
Polimorfismo de Nucleotídeo Único
Limite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Braz. j. oral sci
Assunto da revista:
ODONTOLOGIA
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Brasil