Impact of quality of response on survival outcomes among multiple myeloma patients treated with novel agents - a retrospective analysis
São Paulo med. j
; 140(2): 222-228, Jan.-Feb. 2022. tab, graf
Article
em En
| LILACS
| ID: biblio-1366039
Biblioteca responsável:
BR1.1
ABSTRACT
Abstract BACKGROUND:
In this era of target therapies, novel data on the correlation between response endpoints and survival outcomes in multiple myeloma have arisen.OBJECTIVE:
To determine the impact of quality of response on clinical outcomes, using first-line treatment, and identify risk factors influencing progression-free survival (PFS) and overall survival (OS) among myeloma patients. DESIGN ANDSETTING:
Retrospective analysis on myeloma patients who were treated at the Clinic of Hematology and Clinical Immunology, University Clinical Centre, Niš, Serbia, over a four-year period.METHODS:
A total of 108 newly diagnosed patients who received first-line therapy consisting of conventional chemotherapy or novel agent-based regimens were included in this analysis.RESULTS:
The quality of response to first-line therapy for the whole cohort was classified as follows complete response (CR) in 19%; very good partial response (VGPR) in 23%; partial response (PR) in 38%; and less than PR for the remaining patients. After a median follow-up of 25.4 months, the three-year PFS and OS for the entire study population were 47% and 70%, respectively. Achievement of CR was the main factor associated with significantly prolonged PFS and OS, in comparison with patients who reached VGPR and PR. Likewise, addition of the new drugs bortezomib and thalidomide to standard chemotherapy led to considerably extended PFS and OS, compared with conventional therapy alone.CONCLUSIONS:
This analysis demonstrated that the quality of response after application of first-line treatment using novel agent-based regimens among multiple myeloma patients was a prognostic factor for PFS and OS, which are the most clinically relevant outcomes.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Temas:
Geral
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Tipos_de_cancer
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Outros_tipos
Base de dados:
LILACS
Assunto principal:
Mieloma Múltiplo
Tipo de estudo:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
País/Região como assunto:
Europa
Idioma:
En
Revista:
São Paulo med. j
Assunto da revista:
Cirurgia Geral
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Cincia
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Ginecologia
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MEDICINA
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Medicina Interna
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Obstetr¡cia
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Pediatria
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Sa£de Mental
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Sa£de P£blica
Ano de publicação:
2022
Tipo de documento:
Article